Keto Diet Supplements to Feel Your Best During Ketosis background image
July 26, 2024

Keto Diet Supplements to Feel Your Best During Ketosis

Headshot of Dr. Thomas Wnorowski

Dr. Thomas Wnorowski

PhD, CNCC, Clinical Nutrition Researcher & Biomedical Nutritionist
Headshot of Pooja Mahtani
Medical Review By:

Pooja Mahtani

PHARMD, MS, CNS, LDN, IFMCP, RN

Key Takeaways:

Key Points:

  • The ketogenic diet requires your body to burn fat as its main energy source rather than carbohydrates (aka glucose). This method is helpful for weight loss and can also improve neurodegenerative disorders, metabolic health, and mental health.
  • One of the main roadblocks to the keto diet is something called “keto flu.” It occurs when your body first makes the transition to burning fat as an energy source. During this time, you may experience 1-2 weeks of body aches, digestive issues, moodiness, cravings, and nausea.
  • Keto diet supplements like butyrate, electrolytes, phospholipids, and high-quality fish oil can help mitigate keto flu symptoms and get you results faster.

It’s not just a fad diet.

Dr. Russell Wilder designed the ketogenic diet in the 1920s as a dietary intervention for epilepsy. The results were so promising that keto quickly became a resource for other metabolic and mitochondrial disorders, like diabetes, heart disease, and some neurodegenerative conditions (like Alzheimer's).

Other benefits of the ketogenic diet may include: 

But following the keto diet isn’t for the faint of heart.

The goal is to transition your body from burning carbohydrates to burning fat instead.

This puts your body into ketosis, releasing three essential ketones: acetoacetate, beta-hydroxybutyrate (BHB), and acetone for energy.

Refined sugars and carbohydrates aren’t allowed on the keto diet — even fruits and veggies are only allowed in small portions.

That said, it can certainly be worth overhauling your diet for the metabolic and brain health benefits (especially if your integrative or functional medicine practitioner recommends it).

There are plenty of resources that can ease your transition to the keto diet.

Let’s explore the best keto diet supplements to improve your keto experience.

The Top 10 Keto Diet Supplements We Recommend

If you’re about to start the ketogenic diet, there are big changes on the horizon. The highlights include better blood sugar levels, improved metabolism, and a happier gut microbiome (at least, according to studies).

But like any other restrictive diet, the ketogenic diet has its disadvantages. Especially during the early stages of the diet, nutrient deficiencies and symptoms of “keto flu” are common experiences.

These top ten keto diet supplements can help ease your transition to keto while supporting the promised benefits.

Fish Oil

When switching to a protein- and fat-based diet, you need to become much more conscious of your essential fatty acid intake, especially omega-6s. These are found in high concentrations in nuts, seeds, and seed oils. Omega-6 fatty acids aren’t bad for you, provided they’re responsibly processed and the ideal omega-6 to omega-3 fatty acid ratio for humans is maintained.

Maintaining that ratio can be tricky, though. That’s where a high-quality fish oil supplement comes into play. This powerful keto supplement helps to balance out your fatty acid profile by adding high-quality omega-3s while providing other benefits, like less inflammation through specialized pro-resolving mediators (SPMs). All of these benefits are found in BodyBio’s supplement, Fish Oil+.

Electrolytes

Part of the goal of a traditional keto diet is to significantly reduce carbohydrate intake. The problem is that the body naturally relies on carbohydrates as its main energy source. By eating only fats and protein, we switch from burning carbs to burning ketones — and this process comes with temporary side effects.

The “keto flu” can occur as the body makes this transition — and may cause brain fog, stomach cramps, nausea, and irritability. Intense sugar or carb cravings may be present, too. During this transition, it’s important to persevere and stay well-hydrated with electrolyte supplements. Electrolytes can curb dehydration caused by fluid loss and decrease symptoms of the “keto flu.”

Of course, make sure your electrolyte supplement is keto approved — since many on the market contain dyes, fillers, sugar, and carbohydrate additives. (Hint: BodyBio E-Lyte passes the keto test.)

Magnesium

Magnesium is one of the best supplements for keto dieters.

Not only is magnesium a key electrolyte, but it also keeps your digestive system regular. For a traditional ketogenic diet, plants and fibrous foods are limited — which can lead to temporary constipation. Magnesium helps replenish lost electrolytes while simultaneously improving gut motility.

Because some of the richest sources of magnesium are found in off-limit foods such as whole wheat, whole grains, beans, and legumes, it may be necessary to supplement while following a keto diet.

Sodium Butyrate

In ketosis, the body produces three essential ketones as its primary energy source. The most well-known is B-hydroxybutyrate (or BHB). This ketone is produced in the liver and has a profound impact on the human body.

In studies, BHB decreases oxidative stress, improves gut health, and boosts metabolism. It also has a profound impact on the mitochondria and blood sugar balance and can increase energy throughout the day.

BHB is produced from butyrate — a short-chain fatty acid and postbiotic. Butyrate supplements are a good idea for just about everyone, but they may be especially helpful for ketogenic dieters who want to achieve good BHB production. You may reach ketosis and experience results faster with this BHB-promoting keto diet supplement.

Phospholipids

The ketogenic diet isn’t simply about eating more fat. It’s about eating the right fat. For example, phospholipids are essential for cell membrane function and maintaining cellular health. Paired with high-quality animal foods, nuts, seeds, and essential fatty acids, this keto diet supplement can boost mitochondrial function, initiate a gentle detox, and further support blood sugar balance (one powerful benefit of the keto diet).

Glutathione

A recent study showed that the ketogenic diet actually increased levels of glutathione in children who struggled with epilepsy. We still recommend this keto supplement, though, as a way to replenish antioxidants that could be lost due to limited fruit and veggie intake.

Grass-Fed Beef Liver

A perfect fit for the ketogenic diet, grass-fed beef liver supplements (usually desiccated) are nature’s multivitamin. They deliver iron, vitamin K, vitamin A, copper, selenium, and other nutrients in their bioavailable form. Due to the nutrient density of high-quality organ meats, they’re a powerful addition to any ketogenic diet. Of course, if you enjoy eating them as whole foods, that’s even better.

Fat Soluble Vitamins: A, D, E, and K

If your body is used to a low-fat diet (commonly recommended until just a few years ago), you may experience key vitamin deficiencies. Fat-soluble vitamins are well-absorbed only when dietary fats are present.

Meaning, without dietary fats, you can still consume these nutrients but struggle to metabolize them (aka get them into your cells).

The ketogenic diet offers a unique opportunity to address these nutrient deficiencies head-on — since healthy fats are the main dietary component.

We recommend testing your nutrient levels with an integrative or functional medicine practitioner before supplementing with fat-soluble vitamins to avoid an overdose. If your nutrient levels are low, fat-soluble vitamin supplements (or foods like grass-fed liver) can help you regain energy, vibrancy, and immune system function.

B Vitamins

Some ketogenic dieters may experience vitamin B deficiencies, especially if they’re used to consuming mostly plants and grains as a primary source of fuel. B vitamin deficiencies usually resolve on keto (especially if you’re eating grass-fed beef liver), but it can be helpful to supplement at the beginning. It’s also commonly depleted in people with chronic illnesses and gut dysbiosis.

Consider a methylated B vitamin complex if you’re low on energy, have a slow metabolism, or struggle to lose weight.

High-Quality Probiotics

We rarely recommend probiotics as a stand-alone supplement. This is because the gut ecosystem needs a balance of prebiotics, probiotics, and postbiotics to truly thrive. In the case of the ketogenic diet, though, specific probiotics can help maintain an active gut ecosystem if fibrous foods (or prebiotics) are limited in the diet.

Ideally, you can work with an integrative or functional medicine practitioner who can help you find the probiotic strains that work well with your gut and microbiome.

Be an Advocate for Your Nutritional Health

Knowledge of nutrition and cellular health is essential to protecting your body and mind from chronic disease. The reality is that very few modern foods are nutritionally complete, and even many healthy foods are now heavily processed.

It’s up to us to become experts in nutrition and food quality to deeply nourish our bodies and protect them from harm.

Fish Oil+ is our newest supplement designed to support a healthy inflammatory response, nourish your brain, and fortify your cells with pure, non-oxidized omega-3s.* If you need omega-3 support while following a keto diet, Fish Oil+ is the best of the best.

Maintain Healthy Fatty Acid Balance

Related Articles

Semaglutide Can Change What People Want to Eat. Here's What Your Gut Has to Do With It.
Ashley Palmer | 10.27.2026

Semaglutide Can Change What People Want to Eat. Here's What Your Gut Has to Do With It.

Imagine you order the meal you've loved for a decade, and a few bites in, you realize you just don't care about it. You're not full, exactly. Just uninterested.

Many people taking semaglutide (a GLP-1 medication) describe this experience. Foods that were reliable favorites suddenly seem greasy, or too sweet, or just vaguely off. Scientific American captured the strangeness: a former food writer losing interest in cooking, longtime favorites tasting wrong.

The obvious explanation is that these medications make you feel full sooner. But fullness doesn't explain why a specific curry tastes bitter now, or why a go-to wine suddenly tastes off. Something more is happening, and it points to a hormone your body has been producing your whole life.

In this article, we'll look at what the newest research suggests semaglutide does to food preferences, what GLP-1 actually does inside the body, and where your gut microbiome and a short-chain fatty acid called butyrate fit into that system.

Table of Contents:

  • Semaglutide Isn't Only Changing How Much People Eat
  • Your Gut Was Making GLP-1 Long Before Ozempic
  • Where the Microbiome Comes In
  • Can Butyrate Support Natural GLP-1 Production?
  • Why Butyrate Matters Beyond One Hormone
  • Support the System, Not Just the Signal
  • The Bigger Story Your Gut Was Already Telling

Semaglutide Isn't Only Changing How Much People Eat

Researchers are starting to document what users have been describing anecdotally.

A 2026 observational study of hospitalized Japanese patients with type 2 diabetes found that those on semaglutide showed significantly reduced preference for sweet carbohydrates, non-sweet carbohydrates, and non-sweet fats — while preferences for protein and dietary fiber stayed essentially unchanged. This wasn't a blanket loss of interest in food. It was a selective shift.

For someone focused on weight loss, eating less may be the point. Still, a reduced appetite for fats is worth paying attention to, since dietary fats supply essential fatty acids and help the body absorb fat-soluble vitamins.

Taste perception may also contribute. In a 16-week, randomized, placebo-controlled study of 30 women with obesity and PCOS, semaglutide improved overall taste recognition scores and altered brain activity in response to both food images and a sweet solution. In other words, participants' sense of taste sharpened, which may help explain why some foods suddenly seem too strong.

A 2025 study found the opposite: reduced sensitivity across all five basic tastes in people taking GLP-1 medications compared with matched non-users. That means the more accurate takeaway isn't "Ozempic makes food taste different" so much as "GLP-1 signaling reaches further into how we experience food than many researchers expected."

None of these studies settles the question on its own. But together they point somewhere useful: GLP-1 isn't only a satiety signal. It appears to play a role in how appealing food seems in the first place.

Your Gut Was Making GLP-1 Long Before Ozempic

Here's what often gets lost: GLP-1 wasn't invented by a pharmaceutical company.

GLP-1 is a hormone your intestines release on their own, produced mainly by specialized cells called enteroendocrine L-cells. These cells sit in the gut lining, acting as sensors that detect what's arriving from your meal and releasing hormones that coordinate the response.

GLP-1 helps regulate insulin release, slows how quickly the stomach empties, contributes to satiety, and carries information from the gut to the brain. GLP-1 medications didn't create a new pathway. They target one your body was already running.

But there's an important difference, and a lot of wellness marketing glosses over it. Your body's own GLP-1 is broken down within minutes of release. Semaglutide is engineered to resist that breakdown and activate GLP-1 receptors far more strongly, for far longer.

Supporting your body's own GLP-1 signaling through food or the microbiome isn't a lesser version of taking semaglutide. It's a different thing entirely.

Where the Microbiome Comes In

Your gut bacteria eat what you don't digest.

When fermentable fibers and resistant starch reach the colon, bacteria ferment them and produce short-chain fatty acids (SCFAs), mainly acetate, propionate, and butyrate. These aren't waste products. They're signaling molecules, and the cells lining your intestines are built to receive them.

Intestinal cells carry receptors, including FFAR2 (also called GPR43) and FFAR3, that detect short-chain fatty acids. When SCFAs bind these receptors on L-cells, they trigger an internal cascade that can influence the release of gut hormones, including GLP-1 and a related satiety hormone called PYY.

So the pathway is real: fiber arrives, microbes ferment it, metabolites are produced, gut cells sense them, hormones get released, and the gut communicates with the pancreas and the brain. That last link is worth sitting with — your gut and brain are in constant conversation, and food-derived microbial metabolites are part of what they're saying to each other.

The quick version of this compresses to: fiber → butyrate → GLP-1 → less hunger. The actual biology is an ecosystem with many signals, of which butyrate is one.

Can Butyrate Support Natural GLP-1 Production?

The mechanistic evidence is strong. The human evidence is thinner, but still developing.

A small 2026 study in adults with obesity found that oral sodium butyrate combined with L-arginine significantly increased circulating GLP-1. That's encouraging, but the study had only seven participants, butyrate wasn't tested on its own, and participants reported no difference in hunger or fullness.

By contrast, in a 2025 randomized controlled trial of 50 adults with obesity, people taking sodium butyrate alongside a reduced-calorie diet saw reductions in weight, BMI, and waist circumference, but their serum GLP-1 didn't change significantly.

A 2026 randomized, double-blind trial of 46 adults added more nuance. After 12 weeks of sodium butyrate plus a moderately reduced-calorie diet, participants with obesity lost a meaningful amount of weight. Participants who also had type 2 diabetes did not, although their blood sugar control improved.

That pattern echoes an earlier finding. In a 2018 study, four weeks of oral butyrate improved insulin sensitivity in lean men but not in men with metabolic syndrome.

Together, these suggest butyrate's effects depend heavily on metabolic context: who you are, what your microbiome looks like, and where the butyrate ends up. But GLP-1 is only part of the story.

Why Butyrate Matters Beyond One Hormone

Focusing only on GLP-1 undersells what butyrate does.

Butyrate is the primary fuel source for colonocytes, the cells lining your colon. Not a supporting nutrient. Their main energy supply. Those cells use butyrate to power the work of maintaining a functioning gut lining, the barrier that decides what passes from your digestive tract into your body and what doesn't.

This is where the cellular health picture comes together. A well-fueled intestinal lining supports a healthy gut barrier. A healthy barrier supports a stable environment for the microbial community living there. And that community produces metabolites that signal to the rest of the body — including the gut-to-brain communication involved in appetite and satiety.

Butyrate sits at the center of that loop as both fuel and message. That role holds regardless of what the GLP-1 research eventually concludes.

Support the System, Not Just the Signal

The takeaway isn't that you should be trying to maximize GLP-1. Your metabolism and gut function are more complex than one signal.

Lasting metabolic regulation runs on an ecosystem: microbial diversity, adequate fermentable fiber, well-nourished intestinal cells, an intact gut barrier, and steady communication between gut and brain. Semaglutide shows what happens when you push one signal in that system very hard. It doesn't show that one signal is the whole system, or the only way to modulate it.

Feeding that ecosystem starts with fiber-rich whole foods: vegetables, legumes, cooked-and-cooled potatoes and rice (good sources of resistant starch), and other plant foods your gut bacteria can thrive on. Give it time. Gut environments shift over weeks and months, not days.

For targeted support, BodyBio Butyrate provides butyrate in supplement form to support the gut lining and a healthy microbiome.*

The Bigger Story Your Gut Was Already Telling

Semaglutide has taught researchers a great deal about how strongly GLP-1 signaling can influence not just hunger but desires: what sounds good, what tastes right, and what gets left on the plate.

And yet, the more interesting revelation may be how much was already happening without it. Every meal you eat feeds a microbial community that turns fiber into signaling molecules, which intestinal cells read and translate into messages sent onward to your pancreas and your brain. That conversation has been running your entire life.

Butyrate is one voice in that conversation. It fuels the cells that hold your gut barrier together and takes part in the signaling between your microbiome and the rest of your body. Supporting butyrate production in the gut won't replicate a pharmaceutical. It doesn't need to. Feeding the system well is its own goal, and the benefits build gradually, often in small shifts that are easy to miss at first.

Support your gut at the cellular level with BodyBio Butyrate.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

This article is for educational purposes only and is not a substitute for medical advice. If you're taking semaglutide or another GLP-1 medication, talk with your healthcare provider before adding new supplements.

Comprehensive Guide to Butyrate: What it is, Benefits, Side Effects, & More
Ashley Palmer | 06.16.2026

Comprehensive Guide to Butyrate: What it is, Benefits, Side Effects, & More

Butyrate is a necessary component to a balanced microbiome, also working as an inflammation guard*. One of several, short-chain fatty acids created from fermented resistant starches, low butyrate levels have been associated with serious health concerns.

Butyrate and IBS: What Your Gut Cells Actually Need
Ashley Palmer | 04.24.2026

Butyrate and IBS: What Your Gut Cells Actually Need

You've tried the probiotics. You've cleaned up your diet. You're doing everything you're supposed to do, and your gut still isn't cooperating.

If you have IBS, that frustration is familiar. Bloating, urgency, unpredictable mornings, the constant guessing game of what's going to set things off.

What often gets missed in the conversation around IBS isn't a trendy new supplement or a stricter elimination diet. It's something more foundational: what your gut's own cells actually need to function.

Here's a closer look at what butyrate does, why IBS and low butyrate levels are closely linked, and how supporting the gut at the cellular level can make a difference.

Table of Contents:

  • Understanding Butyrate

  • How Butyrate Works in the Gut

  • Why This Becomes an Issue for People With IBS

  • Supporting the Body More Effectively

  • Butyrate, IBS, and the Cellular Health Connection

  • How Butyrate Supports IBS Comfort Long-Term

Understanding Butyrate

Butyrate is a short-chain fatty acid (SCFA) produced in the colon when beneficial gut bacteria ferment dietary fiber, specifically resistant starch. It belongs to a class of compounds called postbiotics, the functional byproducts of a healthy microbiome.

Unlike probiotics, which are living bacteria, butyrate is a metabolite. It's a compound your body puts to work directly at the cellular level. Understanding the difference between probiotics and postbiotics, like butyrate, is a useful shift you can make when thinking about gut health.

Why the Body Relies on Butyrate

Your colon is lined with specialized cells called colonocytes. These cells run almost entirely on butyrate, providing up to 90% of their energy needs.

When colonocytes have what they need, they do their job well. They maintain the integrity of the gut lining, regulate what passes into the bloodstream, support a healthy inflammatory response, and help keep gut motility on track. Without enough butyrate, the gut’s main source of energy, the gut simply can't do its job well.

How Butyrate Works in the Gut

Butyrate supports three interconnected systems in the gut: the gut lining, the immune environment, and gut motility.

The gut lining is just one cell layer thick. Butyrate fuels those cells and supports the tight junctions between them, the structural connections that keep the barrier intact and functioning.

At the immune level, butyrate helps the body maintain a balanced inflammatory response in the colon without triggering overactivation. And because it directly influences the rhythmic contractions that move contents through the digestive tract, it plays a meaningful role in the irregular patterns that so many people with IBS experience.

What Happens When Butyrate Levels Are Supported vs. Strained

When butyrate is available in adequate amounts, the gut lining stays resilient, motility is more regular, and digestive comfort improves, whether you have a diagnosis of IBS or not.

If butyrate levels fall short, the gut barrier may become less stable, motility can become unpredictable, and the colon's immune environment may shift. How pronounced these patterns are varies from person to person. Diet, stress, genetics, and microbiome composition all play a role in your body’s patterns too.

Why This Becomes an Issue for People With IBS

Modern Stressors on Butyrate Production

Butyrate is made by gut bacteria that ferment resistant starch, a type of fiber found in foods like cooked and cooled potatoes, legumes, and underripe bananas. The modern diet is low in these foods. That means many people simply aren't giving their gut bacteria the raw materials they need to produce adequate butyrate levels.

Antibiotic use, chronic stress, and certain medications can also reduce the population of butyrate-producing bacteria in the colon. Over time, that compounds the butyrate production gap.

Why Common Approaches Often Fall Short

Probiotics can be a valuable part of gut health support, but most probiotic strains are not butyrate-producing species. They can shift the microbiome, but they don't directly address the fuel shortage that many IBS-related symptoms may stem from.

Fiber-based approaches come with a similar challenge. In some people with IBS, increasing fermentable fiber can worsen bloating and gas before it helps, because a disrupted microbiome may not efficiently use that fiber to make butyrate.

Since butyrate works at the cellular level, the signs of low butyrate can overlap common IBS symptoms, which is part of why the connection between the two gets overlooked.

Supporting the Body More Effectively

Foundational Support for Butyrate Production

Diet is the first step to improving the body's natural butyrate production. Foods high in resistant starch give butyrate-producing bacteria what they need to function properly.

Foods that naturally support butyrate production include cooked and cooled rice, potatoes, and legumes. A steady intake of resistant starch over time does more for the microbiome than occasional high-fiber days followed by low-fiber ones.

Stress management and adequate sleep can also support a more stable gut environment. Chronic stress directly affects microbiome composition and motility through the gut-brain axis. 

When Targeted Butyrate Support Makes Sense

For people whose microbiome is disrupted or whose diet can't consistently provide enough resistant starch, direct butyrate supplementation is another option for long-term support.*

Supplemental butyrate delivers the short-chain fatty acid directly to the colon, where colonocytes can put it to use.* Clinical research has shown that sodium butyrate supplementation is associated with improvements in abdominal comfort and bowel regularity in people with IBS.

Sodium butyrate and calcium magnesium butyrate are both effective options, and the differences between which works best for your body often come down to your individual health history and mineral needs.*

Butyrate, IBS, and the Cellular Health Connection

IBS is complex, and its causes vary from person to person. But one consistent finding in the research is that people with IBS tend to have lower levels of butyrate-producing bacteria and overall reduced short-chain fatty acids in the gut. That points to a cellular resource problem as much as a microbiome problem.

When the cells lining the colon are undersupported, the entire digestive environment becomes less stable. Gut barrier function, motility, immune signaling, and communication along the gut-brain axis all depend on colonocytes having what they need to function.

Supporting the gut at the cellular level is not a replacement for other gut health practices (whole food probiotics, exercise, etc.). It’s the foundation that makes those practices more effective. When your cells are supported, the body functions more efficiently as a whole.

How Butyrate Supports IBS Comfort Long-Term

IBS can feel like a moving target, and the path toward better digestive comfort is rarely a straight line or a quick fix. Supporting your gut at the cellular level creates a more stable foundation, and that starts with making sure colonocytes have the fuel they need.*

Butyrate works best as part of a consistent approach that includes diet, lifestyle, and targeted support where needed. Progress tends to be gradual, and that's expected. It reflects the time it takes for the gut lining to strengthen and the microbiome to rebalance.

IBS makes a lot more sense when you know what the gut's cells actually need. And that clarity is often where real progress begins.

Support your gut at the cellular level with BodyBio Butyrate.*